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In this article, it is argued that the North American industrial district was a metropolitan-centred one that drew extensively on regional resources, skills, capital, and information. The Chicago printing industry between 1880 and 1950 is used as a case study to demonstrate that industries were linked at various scales: from the factory district to the metropolis and the region. A wide range of sources (manufacturing censuses, government reports, industrial journals, bankruptcy records) is employed to establish how the intricate set of relations and transactions formed metropolitan industrial districts.